Mechanism of action Alendronate inhibits osteoclast-mediated bone-resorption. Like all bisphosphonates, it is chemically related to inorganic pyrophosphate, the endogenous regulator of bone turnover.
How does alendronate work in the body?
Alendronate works by slowing bone loss. This effect helps maintain strong bones and reduces the risk of broken bones (fractures). Alendronate belongs to a class of drugs called bisphosphonates.
What is the mechanism of action of bisphosphonates?
Mechanism of action — The bisphosphonates inhibit osteoclastic bone resorption via a mechanism that differs from that of other antiresorptive agents [2-4]. Bisphosphonates attach to hydroxyapatite binding sites on bony surfaces, especially surfaces undergoing active resorption.
What does alendronate do for the bones?
Alendronate controls osteoporosis and Paget’s disease of bone but does not cure these conditions. It may take 3 months or longer before your bone density begins to increase. Alendronate helps to treat and prevent osteoporosis only as long as it is taken regularly. Continue to take alendronate even if you feel well.
What is the difference between Fosamax and alendronate?
What is Alendronate (Fosamax®)? Alendronate is commonly known by the brand name Fosamax®. Fosamax® is a bisphosphonate and is used in the treatment of osteoporosis. Fosamax® decreases the rate bone cells are absorbed.
Can you just stop taking alendronate?
Do not stop using this medicine suddenly without asking your doctor. Tell your doctor if you do weight-bearing exercises, smoke or drink excessively. Your doctor will need to take these into consideration in deciding your dose.
How many years should you take alendronate?
Answer From Ann Kearns, M.D., Ph. D. Bisphosphonates, the most common type of osteoporosis medications, are typically taken for at least 3 to 5 years. After that, your doctor will consider your risk factors in determining whether you should continue to take these or other osteoporosis medications.
What are the contraindications of alendronate?
Who should not take ALENDRONATE SODIUM? low vitamin D levels. low amount of calcium in the blood. atrial fibrillation. inflammation of the tissues surrounding a tooth. achalasia of esophagus, a condition that makes swallowing difficult. inflammation of the esophagus. an ulcer in the esophagus. blockage of the esophagus.
What is the most common side effect of bisphosphonate?
The most common side effects of bisphosphonates are stomach irritation and heartburn, but these problems are often avoided by taking the medication correctly. Other common side effects include: Bone or joint pain, or generalized pain. Muscle cramps or aches.
How do bone resorption inhibitors work?
Bone resorption inhibitors are drugs that inhibit mineralization or resorption of the bone by blocking the action of osteoclasts. They are used to treat postmenopausal and glucocorticoid induced osteoporosis, Paget’s disease of the bone and malignant hypercalcemia.
What happens if you stop taking alendronate sodium?
Alendronate oral tablet is used for long-term treatment. It comes with serious risks if you don’t take it as prescribed. If you stop taking the drug suddenly or don’t take it at all: If you don’t take this drug, you may have a higher risk for bone breaks.
Who should not take alendronate?
You should not take alendronate if you have problems with your esophagus, or low levels of calcium in your blood. Do not take alendronate if you cannot sit upright or stand for at least 30 minutes after taking the medicine. Alendronate can cause serious problems in the stomach or esophagus.
Does alendronate affect blood pressure?
Based on the results, hypertension under drug therapy does not have a negative influence on a 6 month treatment of postmenopausal osteoporosis with alendronate.
Why is alendronate taken once a week?
Administering alendronate (70 mg) once a week effectively provides continuous inhibition of bone resorption because bone resorption by osteoclasts is a slow process that typically requires 2-3 weeks for completion and alendronate remains at active bone remodelling sites for a sustained period and (when present in.
Do you gain weight with Fosamax?
Weight gain isn’t a side effect that you should have while taking Fosamax. In clinical trials, weight gain didn’t occur in people taking Fosamax. However, peripheral edema (swelling in your arms or legs) has been reported by some people since Fosamax was approved by the FDA and released onto the market.
What are the dangers of taking Fosamax?
Doctors prescribe Fosamax to prevent age-related bone damage. The drug can cause minor side effects including abdominal pain, acid regurgitation and constipation. In rare cases, people who take the drug may suffer from serious side effects such as femur fractures, jaw problems and esophageal ulcers.
When should alendronate be stopped?
For patients taking alendronate or risedronate for five years or who received zoledronic acid once yearly for three years, who have a stable BMD, no previous vertebral fractures, and who are at low risk for fracture in the near future, we suggest discontinuing the drug (Grade 2C).
How safe is alendronate?
CONCLUSION: This evidence shows alendronate to be safe and effective; it should be considered the nonhormonal therapy of choice for treating osteoporosis in postmenopausal women at risk for hip and vertebral fractures.
Should you take calcium with alendronate?
Alendronate — Calcium may interfere with the absorption of alendronate, a medication used to treat osteoporosis. Calcium-containing products should be taken at least 2 hours before or after alendronate.
What is the safest osteoporosis drug 2020?
The U.S. Food and Drug Administration today approved Evenity (romosozumab-aqqg) to treat osteoporosis in postmenopausal women at high risk of breaking a bone (fracture).
What does alendronic acid do to the body?
Alendronic acid is a drug used for the treatment of osteoporosis. It works by slowing down the production of the cells that wear down bone (osteoclasts). This helps to improve bone strength and makes the bone less fragile.
How do you treat osteoporosis without medication?
“Weight-bearing exercises force you to work against gravity. They include walking, hiking, jogging, climbing stairs, playing tennis, yoga and dancing. Resistance exercises – such as lifting weights – can also strengthen bones.” Kamhi lays it all out in an article she wrote for Natural Medical Journal.